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S -nitrosocysteine can enter the cells via the L-type amino-acid transporter ( - and GSH will predominantly be a two electron oxidation process leading to GSSG formation ( GSH AS A PHYSIOLOGICAL MODULATOR OF NO HOMEOSTASIS The importance of GSH in protecting the electron transport chain from ONOO - is illustrated by experiments with GSH depleted astrocytes

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Upon entering plant cells, NPs can induce ROS generation, which in turn activates transmembrane ion channels, antioxidant defense systems, and mitogen-activated protein kinases (MAPKs) 103,104