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The authors commented that the observed clinical practice is predominantly the consequence of the off-label regime and the current shortages of the medication ( There are some data that metformin can attenuate weight regain after weight loss and prolong the maintenance of a stable weight after weight loss in PCOS

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A series of placebo-controlled, randomized, double-blind clinical trials investigating intravenous or intranasal administration of GSH showed improvements in motor symptoms, but these improvements lacked statistical significance compared to placebo (203205)

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