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J Endocrinol (2011) 209(2):20310.10.1530/JOE-11-0015 10 MaXMengJJiaMBiLZhouYWangYet alExendin-4, a glucagon-like peptide-1 receptor agonist, prevents osteopenia by promoting bone formation and suppressing bone resorption in aged ovariectomized rats

We are excited about this finding, as it shows that the structured intervention improves not only cognition but also other behaviors that affect brain health, which may increase protection against dementia, said Laura D

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However, the potential reduction in healthcare resource use across both classes suggests a combination of both SGLT2is and oral GLP-1 RAs may confer long-term cost savings compared to SGLT2is and standard of care alone [32, 33]

DPP-4 is expressed in human pancreatic beta cells and its direct inhibition improves beta cell function and survival in type 2 diabetes