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However, the observational nature of our study limits the availability of variables such as treatment adherence or lifestyle factors, which may contribute to response heterogeneity

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Reported side effects are rare and typically mild: mild redness or irritation at the application site (usually resolves with continued use or concentration adjustment), occasional skin tingling at higher concentrations (typically benign), and temporary dryness during initial use

Depress the plunger slowly over 5 to 10 seconds

The CDR region was identified by both Chothia and Kabat methods from the online tool AbRSA [ and Novo Pro [ Molecular dynamics simulations As shown in Fig