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in compound nevi, the lesional cells exist in the junctional and underlying connective tissue area

Traditional pharmacological therapies, including corticosteroids and calcineurin inhibitors, suppress aberrant immune activity and reduce inflammation, while antioxidants like vitamins C and E mitigate ROS accumulation (134)

Furthermore, the long non-coding (lnc)RNA KCTD21-AS1, modified by METTL14-mediated N6-methyladenosine methylation, acts as a competing endogenous RNA for miR-519d-5p to regulate CD47 and TIPRL expression, thereby modulating macrophage phagocytosis and autophagy in LC cells (24)

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Mousa, Desanka Cenic-Milosevic, Danimir Jevremovic & Esma R