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They work internally by affecting melanin production or acting as antioxidants to potentially lighten the skin over time

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Mol Cell Biochem 480 , 46714695 (2025)

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3.4 Metformin and doxorubicin-induced cardiotoxicity Doxorubicin (DOX), a potent anthracycline chemotherapeutic, is widely used in oncology but its clinical utility is limited by dose-dependent cardiotoxicity

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