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The article points to people with elevated fasting glucose, significant insulin resistance and preserved pancreatic beta-cell function, the profile where metformin's insulin-sensitizing action has something to work on

The findings showed that chronic (long-term) treatment with Tesofensine increased the expression of BDNF mRNA by 35% in the CA3 region of the hippocampus, and Arc mRNA by 65% in the CA1 region

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