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Poor Solubility and Undissolved Powder Since creatine is an osmotically active compound that attracts water, some forms, such as non-micronized creatine, dont dissolve as well in liquid

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This suggests their potential role in anti-adipogenesis

(PubMed) Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE

Extrapolating an approved HIV-lipodystrophy indication to those uses is exactly the kind of tier-inflation this reference is written to prevent