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The most important genes affecting the pharmacokinetic and pharmacodynamic parameters of warfarin are CYP2C9 (cytochrome P 450 2C9) and VKORC1 (vitamin K epoxide reductase complex subunit 1)

But what makes them appear

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10.1016/j.stemcr.2015.04.004 27 DasS.PanjaP.ChowdhuryG.BiswasS.DholeyY.AdakS

The E-values were notably high, at 4.51 for all-cause mortality, 2.38 for MACEs, and 2.00 for MAKEs, indicating that the observed associations are unlikely to be explained away by potential confounding (Supplemental Table 7)