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4 Potential pathways of exercise to promote bone metabolism through MOTS-c MOTS-c acts on multiple tissues through autocrine, paracrine, and endocrine signaling, playing a role in regulating the metabolism and steady state of the body (Warden and Fuchs, 2021

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Abstract Introduction MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a mitochondrial-derived peptide and regulator of metabolic homeostasis

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Subgroup Analysis To explore potential sources of heterogeneity, we conducted prespecified subgroup analyses in the primary meta-analysis