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The SELECT trial, published in The Lancet (October 22, 2025), provides a landmark analysis confirming that the cardioprotective benefits of semaglutide extend beyond weight loss alone. The SELECT Trial: Study Overview The SELECT trial (NCT03574597) enrolled 17,604 participants aged 45 years and above across 41 countries and 804 sites

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Ozempic is FDA-approved for type 2 diabetes and to reduce the risk of kidney disease progression and cardiovascular death in adults with type 2 diabetes, and as of January 2025, for chronic kidney disease