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the staining intensity grading of all cases was independently and blindly repeated three times by two investigators to ensure the objectivity and reliability of the scoring results

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While mechanistic understanding has advanced, countless studies over the last few decades also brought up many controversies including the identification of specific targets for protein binding and its relevance to toxicity, the role and sources of oxidant stress and lipid peroxidation (LPO), and the importance of inflammation as a mechanism of injury and recovery

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