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When compared to other medications for obesity management, orlistat stands out primarily due to its gastrointestinal side effects which are typically manageable

Eli Lilly's Phase 3 obesity programme for retatrutide (master protocol J1I-MC-GZBJ) remains in active follow-up with no NDA (New Drug Application) or MAA (Marketing Authorisation Application) filing recorded in 20242026 pipeline disclosures [1][2]

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Rapid weight loss and hormonal fluctuations may slow the skins natural ability to rebound without additional support

In addition to these factors, nutritional deficiencies often accompanying rapid weight loss can exacerbate hair loss