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If they help at all, the effect is on the gut ecosystem layer running in parallel to the drug, not on the drug's mechanism itself

doi: 10.1016/j.diabres.2019.05.001 51 PerkovicV.De ZeeuwD.MahaffeyK

If you sit in the insulin-resistant subgroup (the majority of women with PCOS, often with weight challenges and elevated fasting insulin), inositol, NAC, chromium picolinate, and omega-3 are likely your most evidence-aligned options

Lu S, Wang J, Chitsaz F, Derbyshire MK, Geer RC, Gonzales NR, et al

Adenosine signaling is terminated by uptaking adenosine from extracellular space to intracellular space and is then rapidly metabolized to inosine through adenosine deaminase (Morote-Garcia et al., 2008)