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however, dysfunctions in this system culminate in the release of high levels of glucocorticoids, which negatively influence mental health and increase the risk of developing disorders [61]

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Conversely, two mast cell lines do express CB1 and CB2 at both the mRNA and protein level [105] and another study detected CB2 mRNA in rat peritoneal mast cells although administration of 9 -THC dose-dependently released histamine irrespective of the CBRs [106]