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Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

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TB-500 provides broader, systemic regenerative support while BPC-157 targets specific tissue repair, particularly in tendons, ligaments, and the GI tract

Oral supplements with glutathione and vitamin C may also support melanin regulation