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Because ipamorelin produces negligible cortisol and ACTH elevation, any observed downstream effects (IGF-1 changes, body composition shifts, sleep architecture changes) can be attributed to the GH axis rather than needing to be disentangled from concurrent adrenal activation

Besides, it stimulated expression of early growth response 1 (egr-1) gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1-A binding protein-2 (nab2)) (44)

BAFF: a local and systemic target in autoimmune diseases

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