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The initial models were fitted into the EM density map using the UCSF Chimera 1.17.3 23,24 , followed by interactive rounds of manual adjustment and automated refinement in COOT 0.9.8.92 25 and Phenix 1.21 26 , respectively
For example, in elderly individuals, reduced microbial diversity and decreased abundance of beneficial bacteria lead to lower SCFA levels and increased intestinal permeability [170]
doi: 10.14661/1344 37
22 Each clinical pathway is built like a LEGO block, allowing the company to rapidly launch into new therapeutic areas without rebuilding the entire system
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