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Furthermore, GSH plays an essential role in the glutathione-ascorbate cycle, facilitating the reduction of hydrogen peroxide (HO)a highly reactive oxidant that, if not neutralized, can damage lipids, proteins, and DNA (48)

Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase

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Certain enteric pathogens possess mechanisms that enable their direct adherence to IECS while others permit the secretion of effector proteins or enterotoxins via membrane localised secretion systems that typically target TJs thereby increasing intestinal permeability by disrupting the intracellular cytoskeleton of IECs (Knig et al