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For the BTX-A + GLP-1RA cohort, the index event was the earliest date on which patients concurrently met the criteria for overactive bladder, BTX-A injection, and an active GLP-1 receptor agonist prescription (semaglutide or analogues)

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Whereas the predominant irAEs with antiCTLA-4 are colitis and hypophysitis, treatment with an anti-PD1/PD-L1 can cause T1D, hypothyroidism, pneumonitis, and myocarditis, among others

That frenzy is over the imminent expiry of a patent protecting semaglutide, a protein that mimics a hormone telling your brain that youre not hungry