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Sleep Medicine Reviews, 7(3), 215-225

Used in explaining increased frequency of seizures in epilepsy and progression of bipolar disorder in humans. Jason et al have recently (2011) proposed kindling as an etiological model for ME/CFS : Kindling might represent a heuristic model for understanding the etiology of Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS)

However, the PV mature virion is thermally unstable, readily converting from D-antigen to C-antigen upon heating, resulting in a loss of protective immunogenicity 11,12

However, a drug may be toxic in some individuals at concentrations normally tolerated by most other patients

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