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These are precautionary considerations extrapolated from class data

Theyve both tested at 98% purity by HPLC

Structure-activity relationship studies have led to the discovery of non-pyridyl class NAMPT activators, which suggest a through-water interaction mechanism within the NAMPT active site 223

Despite these limitations, ongoing investigation is expected to yield deeper insights into the mitochondrial pathophysiology of AKI and support the development of more effective and clinically translatable therapeutic strategies