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Imaging: For injuries, imaging can document structural changes over time

For instance, membrane-bound ER receptors, such as ER localize at the cell surface where they regulate cell signaling mediated by ER produced in the CNS

Because sufficient amounts of IF are needed to bind to B12, and adequate stomach acid is required to activate IF, a deficiency of either can lead to a B12 deficiency and devastating health consequences

Withdrawal rates due to adverse effects serve as a practical measure of real-world tolerability, making this finding especially relevant for clinical application