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Therefore, since the NRF-2 protein is not exposed to KEAP1, it can adopt a translocation to the nucleus and join genetic regions that have detoxifying enzymes as an end product (e.g., NADPH, glutathione peroxidase, ferritin, and heme oxygenase-1) or antioxidant proteins [16,2224]

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During oxidative stress, Keap1 undergoes modifications that inhibit its interaction with Nrf2, allowing Nrf2 to accumulate and activate the expression of antioxidant and cytoprotective genes

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Ann Clin Psychiatry