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7 Despite the utility of this approach, SPS utilizes several organic solvents, including N,N-dimethylformamide (DMF), N-methyl-2-pyrrolidone, and dichloromethane, all of which are associated with toxic effects following exposure to humans and animals

10.1371/journal.pgen.1000193 293 SakellariouG

The window where symptoms are worst is usually the window right after the change

The overlap in nausea risk means patients may attribute worsening symptoms to one drug when both are contributing

Surgery reduces the risk of epilepsy-associated death, and it may also improve depression and anxiety in refractory epilepsy patients