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Given the substantial resource demands of drug development, large sample sizes, extended trial durations, and the financial and physiological burden of certain treatments (e.g., monoclonal antibodies targeting A), it is ethically and scientifically imperative to identify patients for whom benefit is plausible and to avoid unnecessary exposure of those unlikely to respond

Processing a concentrated dose of vitamins and minerals takes metabolic effort, similar to the recovery your body goes through after hard exercise

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10.1016/S0140-6736(08)60073-2 Lancet