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A cross-database search was conducted on MEDLINE, Embase, Web of Science, and Scopus, for all studies available from January 2000 to December 2022, utilizing the following terms (in English and Spanish): vomiting, cyclic, nausea, syndrome, hyperemesis, cannabinoids, pediatrics, epidemiology, diagnosis, treatment, guidelines, consensuses, and review

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Acetylcholine The cholinergic-adrenergic hypothesis of mood disorders, specifically the role of increased cholinergic activity in modulating depressed mood and sleep disturbance, has been supported by preclinical and human pharmacologic studies [212, 213]

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