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Plasma levels of GHK-Cu decline roughly 60% between age 20 and age 60, which tracks closely with the body's decreasing ability to heal and regenerate tissue

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Homozygous and mutated SLC19A3 gene can cause various conditions such as biotin-thiamine responsive basal ganglia disease (BTBGD), lactic acidosis combined with encephalopathy, infantile epileptic spasms, and early childhood encephalopathy induced by disease or trauma