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Why the pairing is plausible The logic for combining them comes from pathway biology: tesamorelin works through the GHRH receptor, while ipamorelin works through the ghrelin/GHS-R1a receptor

The latter effect has been clearly demonstrated in hyperthyroid cats where administration of calcium ipodate was associated with clinical improvement and normalization of serum total T3 concentrations in over 60% of cases (9)

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