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Zhang et al., 2025a

[3] For many, this was the game-changer, obesity treatment was no longer framed as a moral struggle of willpower versus cake. It became a science-backed recalibration of the bodys hunger systems

Studies consistently show that weight regain begins soon after stopping medication and is proportional to the amount of weight originally lost: Semaglutide (Wegovy) : In the STEP 1 extension study, participants who lost an average of 17% of their body weight regained approximately two-thirds of that weight within one year of stopping the medication

Additionally, there's the issue of the 'nutrition transition', where developing countries are shifting towards more processed, Western-style diets