Its development marks a strategic pivot toward oral-first therapeutic models, potentially redefining the landscape of metabolic disease management while alleviating global supply chain limitations
The prebiotic fibers serve as fuel for beneficial gut bacteria, while the probiotic strains directly introduce and reinforce the specific microbial populations associated with metabolic health and GLP-1 activity
These combined effects make movement one of the greatest ways to support healthy GLP-1 levels (Fujiwara et al., 2019)
Interestingly, GLP-1 is also known to decrease the rewarding effects of food intake by interacting with parts of the mesolimbic dopamine system such as the ventral tegmental area (VTA), nucleus accumbens (NAc) [34], and also GABAergic circuits in the laterodorsal tegmental nucleus (LDTg) [35], which makes brain GLP-1R signaling a promising target for the treatment of alcohol and cocaine abuse disorders [36, 37]
Previous studies reported that the administration of the GLP-1R agonist exendin-4 (25 nmol/kg, twice daily) inhibits learning and memory formation through the suppression of synaptic plasticity in the hippocampus of a high fat diet mouse model (Gault et al., 2010