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Careful and targeted patient selection are required, alongside robust education and novel technologies to monitor glucose and ketone levels to mitigate the risks and enhance the beneficial effects of SGLT2i and GLP-1 RA therapy

Though we highlight the space as a promising area of focus for the future of healthcare, immense challenges remain before these drugs are effectively (and widely) integrated into routine clinical care

These findings emphasize the need for a personalized approach in clinical decision-making, balancing efficacy goals with tolerability to optimize adherence and long-term outcomes

Another meta-analysis (50 randomized controlled trials) performed to assess the association between DPP-4is and the risk of HF in T2D patients evidenced that vildagliptin appears to be the safest option with regard to the risk of HF, followed by saxagliptin, sitagliptin, linagliptin, and alogliptin [153]

Glucagon-like receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits