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However, the magnitude of impact for most of these agents to reverse iatrogenic weight gain tends to be modest, particularly once significant weight gain (ie, 7% of initial body weight) has already occurred

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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia 2, a condition that increases the risk for medullary thyroid cancer Routine monitoring with serum calcitonin or thyroid ultrasound is of uncertain value and will likely lead to many incidental findings and unnecessary procedures

Finally, some studies also showed that metformin could synergize with other drugs increasing their anti-cancer effects

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