In fact, when used in combination with cortisones, tretinoin has been known to prevent thinning of the skin (a common side effect of strong cortisones)
Sick day guidance is important: maintain fluid intake where possible, consider oral rehydration solutions for significant fluid losses, check blood glucose more frequently, and test for ketones if unwell (especially if glucose levels are elevated)
The addition of glutathione provides antioxidant protection and brightening effects, while niacinamide and hyaluronic acid further support skin clarity and hydration
S.et al (2008)
Fouron J-C, Fournier A, Proulx F, Lamarche J, Brigas JL, Boutin C, et al