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The fact that the same proteins in these pathways, and even the same mutated residues are involved (Marmion et al., 2023), raises compelling questions, including (i) why the phenotypic presentations are vastly different, and (ii) how we can develop a strategy to identify and predict NDD-related mutations and distinguish them from those related to cancer even though the same residue is mutated

Tirzepatide is a new dual GIPR/GLP-1R agonist recently approved by both the European Medicines Agency and the FDA

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