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In the next sections, we will briefly introduce thiazides, thiazide-like and loop diuretics from a historic perspective to illustrate how the success of one specific class of these diuretics in treating hypertension overshadowed their undesired metabolic effects and reduced our curiosity to study them to better understand their basic and clinical pharmacology

Testosterone serum levels were reduced by 94% by cetrorelix and levels of prostatic specific antigen (PSA) were significantly lower with the antagonist vs given agonists 28