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7f), suggesting that HNF4-regulated cysteine metabolism significantly contributes to cellular sensitivity to MCR

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For instance, HMGB1 can regulate calcium levels through a TLR4/ROS-dependent pathway, leading to calcium leakage from the sarcoplasmic reticulum, a reduction in the amplitude of calcium transients, and decreased cardiomyocyte contractility, which can further aggravate the pathological processes in the heart [307]

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