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All three contain semaglutide but differ in formulation and licensed indications: Ozempic is a weekly injection (up to 2.0 mg) licensed for type 2 diabetes, Wegovy is a weekly injection (2.4 mg) licensed specifically for weight management, and Rybelsus is a daily oral tablet (up to 14 mg) licensed only for type 2 diabetes

This was shown in a study of 86,000 adults with obesity

A one-way ANOVA was performed on log 10 -transformed counts for treatment groups within each strain, with Sidak's post hoc correction for significance after multiple comparisons

doi: 10.1002/14651858.CD004655.pub3

Pragmatic considerations Although the underlying principles of drug development are conveniently categorised into a series of preclinical and clinical phases with recognised achievement criteria, a new medicine for type 2 diabetes must accommodate several particularly complex challenges [9]