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Rat pharmacokinetics Reported oral bioavailability of approximately 38.4% in rats

H 2 O 2 reduced mitochondrial membrane potential and increased ROS production in treated RA-FLS and activation of caspase-3, caspase-9, and Bax to induce FLS apoptosis, a process associated with oxidative stress-mediated activation of macrophage stimulating 1 (Mst1) and inhibition of the AMPK-Sirt1 signaling pathway (129)

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Breaking down the analysis to infer metabolically diverging subsets proved that our immunometabolic profiling strategy segregated naive, central memory, effector memory, terminally differentiated effector memory (T EMRA ), and CD38-expressing T cells (Supplementary Fig