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Pseudoatom corrections: Additional upper-bound corrections are applied for unresolved methyl and methylene groups

domain 2 (residues 118174) is less basic and more hydrophobic and its C-terminus is at the end of p21

These maladjustments, summarized in Table 1, include -cell dysfunction, insulin resistance, and altered growth-related hormone dynamics, which disrupt metabolic homeostasis and impair child growth