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For patients on levothyroxine, TSH decreases during semaglutide treatment may indicate that thyroid medication doses need to be reduced not that the thyroid itself is being affected

Additional benefits observed: Substantial reduction in knee osteoarthritis pain (75.8% reduction in pain scores) Improved cardiovascular risk markers (non-HDL cholesterol, triglycerides, blood pressure) Up to 86% of participants with fatty liver disease achieved normal liver fat levels Early research suggests retatrutide may lead to substantial weight loss in clinical trial settings, but long-term safety, tolerability, and real-world outcomes still need more data

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Front Immunol (2020) 111741:1741

To view a copy of this licence, visit About this article Cite this article Fanelli, G., Raschi, E., Hafez, G