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The peptide's actin-sequestering activity enables the rapid cytoskeletal reorganization required for keratinocyte migration and fibroblast movement into wound sites, with studies showing 2-3 fold increases in migration rates and improved directional persistence compared to untreated controls

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Type 2 Dent disease results from mutations in the ORCL gene that encodes the inositol polyphosphate-5-phosphatase enzyme