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This trial included 3183 patients with uncontrolled T2DM who were either 50 years old with established CV disease or CKD or 60 years old with CV risk factors only randomized to oral semaglutide 14 mg or placebo in addition to standard of care

55,56 Furthermore, a trial conducted in patients without T2DM indicated that liraglutide 3 mg daily provided benefits comparable to those of structured lifestyle changes in improving liver enzymes, insulin resistance, and weight, which are considered effective and fundamental measures for managing and improving MASLD/MASH