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Because the currently available RCTs regarding such medications were designed to evaluate their treatment efficacy but not to detect incidence of neurodegenerative diseases, it would easily miss the occurrence of neurodegenerative diseases and result in potential reporting bias if they were not designed as systematically screening for adverse events

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Several studies have shown that the production technologies of herbal preparations and supplements can contribute to the elimination of pesticides but, if they are very abundant, they can still be detected after treatment, sometimes reaching concentrations of tens or even hundreds of times higher than the MRL allowed by the European Union (Xiao et al., 2019)

Every ten-degree increase in temperature roughly doubles the rate of chemical degradation

Drug Metab Dispos 29:855862 Serbinova E, Khwaja S, Reznick AZ, Packer L (1992) Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart