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386 During cardiac hypertrophy, the expression of ZIP2 was downregulated

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For example, an engineered Saccharomyces cerevisiae strain produces lactate that exerts dual actions: it inhibits macrophage NLRP3 inflammasome signaling, thereby attenuating inflammation, and serves as a cross-feeding substrate for select commensals, promoting beneficial taxa (e.g., Oscillibacter ) while constraining potentially harmful taxa (e.g., Streptococcus

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A significant change in pH affects the structure of all macromolecules, for instance, presence of a higher proportion of H + or low pH solution cleaves DNA double helix strands by protonating the DNA phosphodiester groups and consequently destabilizing the hydrogen bonds linking DNA nitrogenous bases guanine and cytosine (G-C) ( E