To put it shortly, long-term therapy with semaglutide extended patients lives and lowered their risk of ending up in a hospital for cardiovascular reasons
GBD 2021 Adult BMI Collaborators
Because of its high incidence, mortality, disability rate, recurrence and medical costs, stroke has emerged as a serious health problem of general concern
As with all medications affecting pancreatic function and metabolism, ongoing pharmacovigilance continues to monitor for potential adverse effects

Food and Drug Administration GDPR: General Data Protection Regulation GLP-1 RA: Glucagon-like peptide-1 receptor agonist HCO: Healthcare Organization HIPAA: Health Insurance Portability and Accountability Act HR: Hazard ratio ICD-10-CM: International Classification of Diseases, Tenth Revision, Clinical Modification MAKE: Major adverse kidney events MALO: Major adverse liver outcomes MASH: Metabolic dysfunction-associated steatohepatitis MASLD: Metabolic dysfunction-associated steatotic liver disease MACE: Major adverse cardiovascular events MD: Mean difference NAFLD: Non-alcoholic fatty liver disease (historical term) NNT: Number needed to treat PSM: Propensity Score Matching RCT: Randomized controlled trial SGLT2i: Sodium-glucose cotransporter-2 inhibitor SMD: Standardized mean difference STROBE: Strengthening the Reporting of Observational Studies in Epidemiology SUCRA: Surface under the cumulative ranking curve T2DM: Type 2 diabetes mellitus References Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, et al
