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In vitro studies using 3T3-L1 preadipocyte differentiation models have examined the compound's influence on lipolytic enzyme expression and lipogenic transcription factor activity

Neutrophils are among the first immune cell populations to respond to ischemic injury

High-dose oral B12 (10002000 micrograms daily) may be effective even in some malabsorption conditions through passive diffusion

Higher doses of vitamin B 12 supplements are recommended for patients taking medications that interfere with its absorption (see Drug interactions)