Why Your Daily Salad Matters for Your Memory: Every gram of diverse fiber you consume feeds bacteria that produce SCFAs These SCFAs cross your blood-brain barrier and bind to microglial GPR109A receptors This binding triggers HDAC inhibition, changing gene expression patterns The result: microglia switch from inflammatory M1 phenotype to healing M2 phenotype Your brain becomes more resilient to stress, aging, and neurodegeneration The Fermented Food-Brain Connection: Foods like sauerkraut, kimchi, and kefir don't just improve digestion, they're delivering live bacteria that colonize your gut and immediately begin producing neuroprotective metabolites
For instance, it was shown that repeated light-dark shifts in male C57BL/6 mice exacerbated colonic inflammation and tissue damage, pointing to heightened systemic inflammatory responses 125
One of the ways it appears to work is by increasing brain-derived neurotrophic factor, or BDNF, a protein that helps brain cells grow, repair, and form new connections
The left panel details the immobilization strategies for p28 and p53 family members
Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement
