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55 This finding may be explained at least in part by reduced expression of the soluble guanylyl cyclase (sGC), as in different hypertensive animal models, the expression of one or both sGC subunits ( 1 and 1 ), as well as NO-dependent sGC activity were significantly decreased

But I think we just have to think about what are some of the other potential problems that could arise from these drugs. Schrack says older adults who may have issues with balance or bone mass should be mindful that the weight loss on these medications may cause the loss of muscle, not just fat, which may affect stability and fracture risk

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