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The exact mechanism isn't fully understood, but it may relate to blood sugar fluctuations, reduced calorie intake when starting the medication, or dehydration, especially if nausea limits fluid consumption

To view a copy of this licence, visit About this article Cite this article Georgiou, A., Zanos, P

However, the scale and consistency of patient-reported experiences have suggested that these signals merit further investigation

However, semaglutide has a longer track record and more long-term safety data

Semaglutide has a predictable pharmacokinetic profile with a long t 1/2 that allows for once-weekly subcutaneous administration